Antinociceptive interactions between intrathecally administered α noradrenergic agonists and′ 5-N-ethylcar☐ amide adenosine
S Aran, HK Proudfit - Brain Research, 1990 - Elsevier
Recently, it has been shown that intrathecal injection of norepinephrine and the mixed A 1/A
2 adenosine agonist5′-N-ethylcar☐ amide adenosine (NECA) interact in a supra-additive
manner to produce antinociception. The present studies were designed to determined
whetherα 1 orα 2 noradrenergic receptors are involved in producing the antinociception
induced by NECA and norepinephrine. The results indicated that intrathecal injection of
NECA (0.97–4.9 nmol), theα 2 noradrenertic agonist clonidine (3.8–375 nmol), or theα 1 …
2 adenosine agonist5′-N-ethylcar☐ amide adenosine (NECA) interact in a supra-additive
manner to produce antinociception. The present studies were designed to determined
whetherα 1 orα 2 noradrenergic receptors are involved in producing the antinociception
induced by NECA and norepinephrine. The results indicated that intrathecal injection of
NECA (0.97–4.9 nmol), theα 2 noradrenertic agonist clonidine (3.8–375 nmol), or theα 1 …
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